Global RNA editome landscape discovers reduced RNA editing in glioma: loss of editing of gamma-amino butyric acid receptor alpha subunit 3 (GABRA3) favors glioma migration and invasion
نویسندگان
چکیده
منابع مشابه
RNA Editing RNA
RNA Editing RNA editing is a term used to describe a diverse set of phenomena in which mRNA, rRNA, and tRNA transcripts are modified in sequence after transcription. The types of RNA editing vary from uridine (U) or cytidine (C) insertions and deletions within coding regions of mitochondrial mRNAs to the substitution of specific C residues with U residues in plant mitochondrial mRNAs or the sub...
متن کاملRNA editing.
RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum, (c) the C-to-U substitution editing of the ma...
متن کاملDeletions in cox2 mRNA Result in Loss of Splicing and RNA Editing and Gain of Novel RNA Editing Sites
As previously demonstrated, the maize cox2 RNA is fully edited in cauliflower mitochondria. Use of constructs with a deleted cox2 intron, however, led to a loss of RNA editing at almost all editing sites, with only a few sites still partially edited. Likewise, one deletion in exon 1 and three in exon 2 abolish RNA editing at all cox2 sites analyzed. Furthermore, intron splicing is abolished usi...
متن کاملRNA Editing of Cytochrome Oxidase Subunit III in Sunflower Mitochondria.
Direct sequencing of cytochrome oxidase subunit III (coxIII) mRNA with a specific primer confirms RNA editing in sunflower (Helianthus annus) mitochondria. Six instances of mRNA editing could be verified, one of these specific to this species. All the editing events involve C to U transitions in the coxIII mRNA causing codon changes that lead to amino acids better conserved in evolution than th...
متن کاملGenetic mapping uncovers cis-regulatory landscape of RNA editing
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by ADAR enzymes conserved in metazoans, plays an important role in neurological functions. Although the fine-tuning mechanism provided by A-to-I RNA editing is important, the underlying rules governing ADAR substrate recognition are not well understood. We apply a quantitative trait loci (QTL) mapping approach to identify genetic variants ass...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2020
ISSN: 2167-8359
DOI: 10.7717/peerj.9755